- Author:
Bo Ri KIM
1
;
Seungkeol YANG
;
Eun Jin DOH
;
Chong Won CHOI
;
Sang Woong YOUN
Author Information
- Publication Type:Original Article
- Keywords: Adverse effects; Clinical laboratory techniques; Cyclosporine; Psoriasis; Risk factors
- MeSH: Ambulatory Care Facilities; Clinical Laboratory Techniques; Cyclosporine*; Humans; Kidney Diseases; Liver; Male; Psoriasis*; Risk Factors*; Uric Acid
- From:Annals of Dermatology 2018;30(2):143-149
- CountryRepublic of Korea
- Language:English
- Abstract: BACKGROUND: No study to date has focused on the changes in laboratory test results and related risk factors in patients with psoriasis treated with prolonged Cyclosporine A (CsA) therapy. OBJECTIVE: The objective of this study was to investigate the changes of laboratory values and related risk factors in patients with psoriasis treated with CsA in a real-world setting. METHODS: Records of patients with psoriasis treated with CsA at an outpatient clinic were collected, and a Cox proportional hazards regression model was used. RESULTS: Of the 128 patients included in this study, 28 patients (21.9%) showed laboratory test abnormalities over a mean medication period of 11.6 months. Older age (hazard ratio [HR], 1.174; 95% confidence interval [CI], 1.068~1.370; p=0.007) and pre-existing kidney disease (HR, 0.008; 95% CI, 0~0.205; p=0.001) significantly increased the risk of renal dysfunction. Male sex was the only significant risk factor for liver enzyme elevation (HR, 0.284; 95% CI, 0.081~0.784; p=0.026) and uric acid abnormality (HR, 0.048; 95% CI, 0~0.372; p=0.046). CONCLUSION: This is an in-depth analysis of laboratory changes and related risk factors in patients with psoriasis treated with CsA. Liver is the most commonly affected organ of CsA toxicity. Older age, male sex, and presence of kidney disease were risk factors associated with laboratory abnormality during CsA treatment.