Invasive Lobular Carcinoma: Detection and Multiplicity with Multimodalities.
10.12771/emj.2018.41.2.27
- Author:
In Hye CHAE
1
;
Eun Suk CHA
;
Jee Eun LEE
;
Jeoung Hyun KIM
;
Bom Sahn KIM
;
Jin CHUNG
Author Information
1. Department of Radiology, Ewha Womans University College of Medicine, Seoul, Korea. aqua0724@ewha.ac.kr
- Publication Type:Original Article
- Keywords:
Breast;
Invasive lobular carcinoma;
Mammography;
Positron-emission tomography;
Computed tomography
- MeSH:
Breast;
Carcinoma, Lobular*;
Diagnosis;
Electrons;
Female;
Humans;
Magnetic Resonance Imaging;
Mammography;
Pathology, Surgical;
Positron-Emission Tomography;
Positron-Emission Tomography and Computed Tomography;
Ultrasonography
- From:The Ewha Medical Journal
2018;41(2):27-34
- CountryRepublic of Korea
- Language:English
-
Abstract:
OBJECTIVES: We aimed to compare the diagnostic performances of digital mammography (DM), digital breast tomosynthesis (DBT), ultrasound (US), magnetic resonance imaging (MRI), breast specific gamma imaging (BSGI) and/or positron emission tomography/computed tomography (PET/CT) for the detection of invasive lobular carcinoma (ILC). METHODS: Index ILCs and multifocal/multicentric (multiple) ILCs were analyzed using various imaging modalities. The final surgical pathology was regarded as the reference standard. The detection rate for index cancers and the diagnostic performance for multiple ILCs per breast were evaluated. RESULTS: Seventy-eight ILCs in 76 women were enrolled. Twenty-six breasts had multiple ILCs. DM (n=72), DBT (n=15), US (n=77), MRI (n=76), BSGI (n=50), and /or PET/CT (n=74) were performed. For index cancer, the detection rate was 100% for DBT, US, and MRI. For multiple ILCs, the sensitivity was 100% for DBT and MRI (P<0.001). The diagnostic accuracy for multiple ILCs were 73.3% for DBT and 73.0% for PET/CT (P=0.460). CONCLUSION: DBT was the most accurate imaging modality for both index and multiple ILCs. PET/CT was also valuable for multiple ILCs, whereas DM and BSGI showed relatively low diagnostic performances. DBT and PET/CT have promising roles in the diagnosis of multiple ILCs.
