Primary Cilia as a Signaling Platform for Control of Energy Metabolism.
10.4093/dmj.2018.42.2.117
- Author:
Do Kyeong SONG
1
;
Jong Han CHOI
;
Min Seon KIM
Author Information
1. Division of Endocrinology and Metabolism, Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea. mskim@amc.seoul.kr
- Publication Type:Review
- Keywords:
Cilia;
Hedgehogs;
Metabolism;
Obesity;
Wnt signaling pathway
- MeSH:
Adipose Tissue;
Alstrom Syndrome;
Bardet-Biedl Syndrome;
Basal Bodies;
Body Weight Maintenance;
Cilia*;
Delivery of Health Care;
Energy Metabolism*;
Hedgehogs;
Metabolism;
Neurons;
Obesity;
Organelles;
Wnt Signaling Pathway
- From:Diabetes & Metabolism Journal
2018;42(2):117-127
- CountryRepublic of Korea
- Language:English
-
Abstract:
Obesity has become a common healthcare problem worldwide. Cilia are tiny hair-like organelles on the cell surface that are generated and anchored by the basal body. Non-motile primary cilia have been considered to be evolutionary rudiments until a few decades, but they are now considered as important signaling organelles because many receptors, channels, and signaling molecules are highly expressed in primary cilia. A potential role of primary cilia in metabolic regulation and body weight maintenance has been suspected based on rare genetic disorders termed as ciliopathy, such as Bardet-Biedl syndrome and Alström syndrome, which manifest as obesity. Recent studies have demonstrated involvement of cilia-related cellular signaling pathways in transducing metabolic information in hypothalamic neurons and in determining cellular fate during adipose tissue development. In this review, we summarize the current knowledge about cilia and cilia-associated signaling pathways in the regulation of body metabolism.
