Association of Adiponectin 45T/G Polymorphism with Diabetic Cardiovascular Complications in Korean Type 2 Diabetes.
10.3346/jkms.2018.33.e124
- Author:
Myeong Jin JI
1
;
Eu Jeong KU
;
Tae Keun OH
;
Hyun Jeong JEON
Author Information
1. Department of Internal Medicine, SynWoo Hospital, Seongnam, Korea.
- Publication Type:Original Article
- Keywords:
Type 2 Diabetes;
Adiponectin;
Cardiovascular Complication;
Polymorphism
- MeSH:
Adipokines;
Adiponectin*;
Alleles;
Cardiovascular Diseases;
Genotype;
Glucose;
Humans;
Metabolism;
Prevalence
- From:Journal of Korean Medical Science
2018;33(17):e124-
- CountryRepublic of Korea
- Language:English
-
Abstract:
BACKGROUND: Adiponectin is an adipokine that regulates lipid and glucose metabolism and has been shown to have anti-inflammatory and anti-atherogenic effects. It also plays an important role in the development of cardiovascular disease (CVD). METHODS: This study evaluated the association between adiponectin 45T/G polymorphism and cardiovascular complication in type 2 diabetes in Koreans. RESULTS: The present study included 758 patients with type 2 diabetes. The distribution of the adiponectin 45T/G polymorphism was 3.56% (n = 27) for GG, 42.35% (n = 321) for TG, and 54.09% (n = 410) for TT in patients with type 2 diabetes. The prevalence of CVD was significantly higher in subjects with the GG + TG genotype compared to those with the TT genotype (17.5% vs. 9.8%, P = 0.002). The G allele was associated with a higher risk of CVD (P = 0.002). CONCLUSION: Our findings suggest that the adiponectin 45T/G polymorphism is associated with diabetic cardiovascular complication in type 2 diabetes.
