Anaplastic Large Cell Lymphoma with Massive Eosinophilia and Complex Karyotype Initially Misdiagnosed as Chronic Eosinophilic Leukemia.
- Author:
Min Kyung SO
1
;
Sholhui PARK
;
Min Sun CHO
;
Yeung Chul MUN
;
Jungwon HUH
Author Information
- Publication Type:Brief Communication
- Keywords: Hypereosinophilia; Metaphase cytogenetics; Interphase fluorescence in situ hybridization; Anaplastic large cell lymphoma; Chronic eosinophilic leukemia
- MeSH: Bone Marrow; Cytogenetics; Diagnosis; Eosinophilia*; Eosinophils*; Fluorescence; Follow-Up Studies; Humans; Hypereosinophilic Syndrome*; In Situ Hybridization; Interphase; Karyotype*; Lymphoma; Lymphoma, Large-Cell, Anaplastic*; Masks; Metaphase; Microscopy
- From:Laboratory Medicine Online 2018;8(2):56-61
- CountryRepublic of Korea
- Language:English
- Abstract: We report a patient with massive eosinophilia and a complex karyotype that was initially misdiagnosed as chronic eosinophilic leukemia (CEL), but later diagnosed as anaplastic large cell lymphoma (ALCL) masked by massive eosinophilia. The complex karyotype observed at initial diagnosis remained unchanged later, after the evidence of bone marrow involvement of ALCL was obtained. At diagnosis, genetic aberrations corresponding to metaphase cytogenetics were not identified by interphase fluorescence in situ hybridization, although abnormal results were noted at follow-up. Together, these observations indicate that the complex karyotype at initial work-up has been derived from a low proportion of lymphoma cells with high mitotic ability that were not identified by microscopy, rather than from massive eosinophils. These findings suggest that our patient had ALCL with secondary eosinophilia rather than CEL since initial diagnosis.
