Analytical Performance of New ARCHITECT AFP Assay: Comparison with the Current Assay.
- Author:
Kwang Sook WOO
1
;
Gyu Dae AN
;
Hyeon Ho LIM
;
Jin Yeong HAN
Author Information
- Publication Type:Brief Communication
- Keywords: Alpha-fetoprotein; ARCHITECT AFP assay; Analytical performance
- MeSH: alpha-Fetoproteins; Carcinoma, Hepatocellular; Diagnosis; Methods
- From:Laboratory Medicine Online 2018;8(2):62-65
- CountryRepublic of Korea
- Language:English
- Abstract: Alpha-fetoprotein (AFP) is frequently used for hepatocellular carcinoma (HCC) diagnosis and surveillance. Although the current ARCHITECT AFP (List number 7K67) assay range is 0–350 ng/mL, all samples with test results between 200 and 350 ng/mL must be diluted and retested until their levels are <200 ng/mL. A new ARCHITECT AFP (8100/3P36) assay with a dynamic range of up to 2000 ng/mL has been introduced. The aim of this study was to perform a method comparison between the current ARCHITECT AFP assay and the new assay. The precision study showed excellent results for both high and low controls. There was a positive correlation between the two assay systems and clinical samples. The new ARCHITECT AFP assay with a wide assay range demonstrated good analytical performance. Therefore, the current ARCHITECT AFP assay could be replaced by the new assay, which is more convenient and minimizes manual labor.
