Successful Treatment of Cisplatin Overdose with Plasma Exchange.
10.3349/ymj.2002.43.1.128
- Author:
Jae Hyuck CHOI
1
;
Jane C OH
;
Kang Ho KIM
;
So Young CHONG
;
Myoung Seo KANG
;
Do Yeun OH
Author Information
1. Department of Internal Medicine, College of Medicine, Pochon CHA University, 351 Yatap-dong, Pundang-gu, Sungnam-city, Kyunggi-do 463- 712, Korea. doh@cha.ac.kr
- Publication Type:Case Reports
- Keywords:
Cisplatin overdose;
plasma exchange
- MeSH:
Antineoplastic Agents/*poisoning;
Case Report;
Cisplatin/*poisoning;
Human;
Male;
Middle Age;
Overdose/therapy;
*Plasma Exchange
- From:Yonsei Medical Journal
2002;43(1):128-132
- CountryRepublic of Korea
- Language:English
-
Abstract:
We report a 48-year-old man with laryngeal cancer who received a massive cisplatin toxic overdose without intravenous prehydration through an error in prescription. He received 400 mg/m2 of cisplatin over a 4-day period. On day 4, he exhibited a broad range of cisplatin toxicities and emergency plasma exchange was started. From day 5 through 19, he underwent 9 cycles of plasma exchange and his plasma cisplatin concentration decreased from 2,470 ng/ml to 216 ng/ml. He completely recovered without any sequelae. No previous reports exist in the English literature of survival without complication after the administration of such a high cisplatin dosage without prehydration.
