The Role of B Cells in Transplantation Rejection.
10.4285/jkstn.2018.32.1.1
- Author:
Tae Jin KIM
1
Author Information
1. Division of Immunobiology, Sungkyunkwan University School of Medicine, Suwon, Korea. tjkim@skku.edu
- Publication Type:Review
- Keywords:
B cell;
Transplant rejection;
Antibody diversity;
Helper T cell;
B-1 cell
- MeSH:
Antibodies;
Antibody Diversity;
Antigen-Presenting Cells;
B-Lymphocytes*;
B-Lymphocytes, Regulatory;
Graft Rejection*;
Isoantigens;
Major Histocompatibility Complex;
T-Lymphocytes;
T-Lymphocytes, Helper-Inducer
- From:The Journal of the Korean Society for Transplantation
2018;32(1):1-6
- CountryRepublic of Korea
- Language:English
-
Abstract:
B cells play a role in graft rejection via several mechanisms. Specifically, B cells produce high-affinity antibodies to alloantigens including allogeneic major histocompatibility complex (MHC) with the help of follicular helper T cells. B cells also function as antigen-presenting cells for alloreactive T cells, resulting in the activation of alloreactive T cells. Conversely, the frequency of regulatory B cells increases under inflammatory conditions and suppresses the rejection process. Here, the differential roles of the major B cell subpopulations (B-1, follicular B, marginal zone B, and regulatory B cells) involved in transplantation rejection are discussed together with their interaction with T cells.
