Sudden Deaths of Neonates Receiving Intravenous Infusion of Lipid Emulsion Contaminated with Citrobacter freundii.
- Author:
Ji Yun BAE
1
;
Chang Kyung KANG
;
Su Jin CHOI
;
Eunyoung LEE
;
Pyoeng Gyun CHOE
;
Wan Beom PARK
;
Nam Joong KIM
;
Eui Chong KIM
;
Myoung don OH
Author Information
- Publication Type:Brief Communication
- Keywords: Neonate; Sudden Death; Citrobacter freundii; Fat Embolism; Intravenous Fat Emulsions
- MeSH: Bacteria; Citrobacter freundii*; Citrobacter*; Death, Sudden*; Embolism, Fat; Fat Emulsions, Intravenous; Humans; Hydrogen-Ion Concentration; In Vitro Techniques; Infant, Newborn*; Infusions, Intravenous*; Intensive Care Units; Kinetics; Sepsis
- From:Journal of Korean Medical Science 2018;33(10):e97-
- CountryRepublic of Korea
- Language:English
- Abstract: At an intensive care unit, four neonates died consecutively within 80 minutes. Citrobacter freundii was isolated from blood samples of the 4 patients. It was also cultured from the leftover SMOFlipid that had been infused intravenously into the patients. In this in vitro study, we evaluated the bacterial growth kinetics and change in size of fat globules in SMOFlipid contaminated with C. freundii. Following the growth of bacteria, pH of SMOFlipid decreased to < 6, and the number of fat globules larger than 5 µm increased. Pulmonary fat embolism is proposed as a possible cause of the sudden deaths as well as fulminant sepsis.
