Diagnostic Performance of %-2proPSA and Prostate Health Index for Prostate Cancer: Prospective, Multi-institutional Study.
- Author:
Hongzoo PARK
1
;
Sang Wook LEE
;
Geehyun SONG
;
Tae Wook KANG
;
Jae Hung JUNG
;
Hyun Chul CHUNG
;
Sung Jin KIM
;
Chang Hoo PARK
;
Jong Yeon PARK
;
Tae Young SHIN
;
In Bum SUH
;
Jeong Hyun KIM
Author Information
- Publication Type:Multicenter Study ; Original Article
- Keywords: Biomarkers; Biopsy; Early Diagnosis; Prostatic Cancer; Prostate-specific Antigen
- MeSH: Biomarkers; Biopsy; Early Diagnosis; Humans; Logistic Models; Male; Neoplasm Grading; Observational Study; Passive Cutaneous Anaphylaxis; Prospective Studies*; Prostate*; Prostate-Specific Antigen; Prostatic Neoplasms*; ROC Curve
- From:Journal of Korean Medical Science 2018;33(11):e94-
- CountryRepublic of Korea
- Language:English
- Abstract: BACKGROUND: We evaluated the clinical performance of [-2]proPSA (p2PSA) and its derivatives in predicting the presence and aggressiveness of prostate cancer (PCa) in Korean men. METHODS: A total of 246 men with total prostate-specific antigen (tPSA) ≥ 3.5 ng/mL who underwent their first prostate biopsy were included in this prospective, multicenter, observational study. Diagnostic accuracy of tPSA, free-to-total PSA ratio (%fPSA), p2PSA, %p2PSA, and the Beckman Coulter prostate health index (PHI) was assessed by receiver operating characteristic curve analyses and logistic regression analyses. RESULTS: Overall, PCa was detected in 125 (50.8%) subjects. In men with tPSA 3.5–10 ng/mL, the detection rate of PCa was 39.4% (61/155). In this group, PHI and %p2PSA were the most accurate predictors of PCa and significantly outperformed tPSA and %fPSA; area under the curve for tPSA, %fPSA, %p2PSA, and PHI was 0.56, 0.69, 0.74, and 0.76, respectively. PHI was also the strongest predictor of PCa with Gleason score ≥ 7. CONCLUSION: This study demonstrates the superior clinical performance of %p2PSA and PHI in predicting the presence and aggressiveness of PCa in Korean men. The %p2PSA and PHI appear to improve detection of PCa and provide prognostic information.
