Protective effects of cultured and fermented ginseng extracts against scopolamine-induced memory loss in a mouse model.
- Author:
Song Hee HAN
1
;
Sung June KIM
;
Young Won YUN
;
Sang Yoon NAM
;
Hu Jang LEE
;
Beom Jun LEE
Author Information
- Publication Type:Retracted Publication ; Original Article
- Keywords: Memory loss; ginsenosides; scopolamine; acetylcholine; mice
- MeSH: Acetylcholine; Acetylcholinesterase; Animals; Body Weight; Brain-Derived Neurotrophic Factor; Ginsenosides; Humans; Learning; Male; Memory Disorders*; Memory*; Memory, Short-Term; Mice*; Mice, Inbred ICR; Models, Animal; Panax*; Scopolamine Hydrobromide; United Nations; Water
- From:Laboratory Animal Research 2018;34(1):37-43
- CountryRepublic of Korea
- Language:English
- Abstract: This study was performed to investigate the effect of a concentrate of fermented wild ginseng root culture (HLJG0701) on memory improvement in the scopolamine (SPL)-induced memory-deficient mouse model. Eight-week-old male ICR mice were used to evaluate the protective effect of HLJG0701 against the SPL-induced memory loss animal model. The Morris water maze test, which measures hippocampus-dependent learning ability, and the Y-maze test, a short-term memory assessment test, were performed and related markers were analyzed. HLJG0701-treated groups displayed significantly reduced acetylcholinesterase activity and increased acetylcholine level compared with the SPL-administered group (SPL-G) (P < 0.05). In the Y-maze test, the spontaneous alternation in al HLJG0711-treated groups was significantly increased compared with that in SPL-G (P < 0.05). In the Morris water maze test, the escape latency and time spent in the target quadrant in all HLJG0701-treated groups were significantly decreased and increased, respectively, compared with those in SPL-G (P < 0.05). In addition, the brain-derived neurotrophic factor level in groups treated with HLJG0701 300 and 600 mg/kg body weight was significantly increased compared with that in SPL-G (P < 0.05). These results suggest that the HLJG0701 may protect against memory loss by inhibiting acetylcholinesterase activity and preventing acetylcholine deficiency.
