Low levels of 25-hydroxyvitamin D in children and adolescents with type 1 diabetes mellitus: a single center experience.
10.6065/apem.2018.23.1.21
- Author:
Ki Nam BAE
1
;
Hyo Kyoung NAM
;
Young Jun RHIE
;
Dae Jin SONG
;
Kee Hyoung LEE
Author Information
1. Department of Pediatrics, Korea University College of Medicine, Seoul, Korea. muguet@korea.ac.kr
- Publication Type:Original Article
- Keywords:
Diabetes mellitus;
Type 1;
Vitamin D deficiency;
Child;
Case-control studies
- MeSH:
Adolescent*;
Adult;
Body Mass Index;
C-Peptide;
Case-Control Studies;
Child*;
Diabetes Mellitus;
Diabetes Mellitus, Type 1*;
Diagnosis;
Hemoglobin A, Glycosylated;
Humans;
Insulin;
Logistic Models;
Prevalence;
Seasons;
Vitamin D;
Vitamin D Deficiency
- From:Annals of Pediatric Endocrinology & Metabolism
2018;23(1):21-27
- CountryRepublic of Korea
- Language:English
-
Abstract:
PURPOSE: Low vitamin D level is common in adults with diabetes mellitus (DM). We assessed vitamin D level and its associated factors in Korean youth with type 1 DM. METHODS: Type 1 DM cases (n=85) and healthy controls (n=518) aged < 20 years were included and grouped into 3 categories according to vitamin D level: deficiency ( < 20 ng/mL), insufficiency (20–30 ng/mL), or sufficiency (≥30 ng/mL). RESULTS: The mean serum vitamin D level was significantly lower (21.6±8.5 ng/mL vs. 28.0±12.0 ng/mL, P < 0.001) and vitamin D deficiency prevalence was significantly higher (48% vs. 26%, P < 0.001) in type 1 DM cases than in healthy controls. Logistic regression analysis revealed that type 1 DM cases were more likely to have vitamin D deficiency (P=0.004), independent of sex, age, and body mass index. Type 1 DM cases with vitamin D deficiency/insufficiency were mainly diagnosed in winter (November to April) (P=0.005), and the duration of diabetes was longer than in those with vitamin D sufficiency (P=0.046). However, season of diagnosis, duration of diabetes, prescribed daily insulin dose, and glycosylated hemoglobin and C-peptide levels were not associated with 25-hydroxyvitamin D (25(OH)D) level in type 1 DM cases after adjustment for other factors. CONCLUSIONS: We recommend assessment of serum 25(OH)D level in type 1 DM cases and to treatment if findings indicate insufficiency. Further studies investigating the mechanisms underlying vitamin D deficiency in youth with type 1 DM are needed.
