IgG4-related Skin Disease: Experience with Two Cases.
- Author:
Jinhyup LEE
1
;
Jiyoung KIM
;
Seulki LIM
;
Myung IM
;
Young LEE
;
Youngjoon SEO
;
Jeunghoon LEE
Author Information
1. Department of Dermatology, College of Medicine, Chungnam National University, Daejeon, Korea. jhoon@cnu.ac.kr
- Publication Type:Case Report
- Keywords:
IgG4-related disease
- MeSH:
Adrenal Cortex Hormones;
Biopsy;
Dermis;
Diagnosis;
Immunoglobulin G;
Plasma Cells;
Pruritus;
Sensation;
Skin Diseases*;
Skin*
- From:Korean Journal of Dermatology
2018;56(3):197-201
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
IgG4-related disease (IgG4-RD) is a new disease entity characterized by elevated serum IgG4 and infiltration of IgG4+ plasma cells in tissue. IgG4-RD can involve various organs, and skin could also be affected. The manifestations of IgG4-related skin disease (IgG4-RSD) are not characteristic, however it usually presents with multiple erythematous nodules or plaques with itching sensation. We report two cases of IgG4-RSD. Histological studies of these cases revealed infiltration of numerous plasma cells and mononuclear cells in the entire dermis. Some plasma cells were strongly positive for IgG4 stain. IgG4-RSD is a treatable disease with systemic corticosteroids. Thus, clinicians should obtain a biopsy and identify IgG4-positive cells for an accurate diagnosis.
