The Association between Fat Mass, Lean Mass and Bone Mineral Density in Premenopausal Women in Korea: A Cross-Sectional Study.
10.4082/kjfm.2018.39.2.74
- Author:
Jeehyun KIM
1
;
Hyuktae KWON
;
Bo Kyoung HEO
;
Hee Kyung JOH
;
Cheol Min LEE
;
Seung Sik HWANG
;
Danbee PARK
;
Jae Hong PARK
Author Information
1. Department of Family Medicine, Seoul National University Hospital, Seoul, Korea. ezkel@snuh.org, ultraman123@naver.com
- Publication Type:Original Article
- Keywords:
Bone Density;
Fat Mass;
Lean Mass;
Premenopause;
Osteoporosis
- MeSH:
Absorptiometry, Photon;
Body Composition;
Body Mass Index;
Bone Density*;
Cross-Sectional Studies*;
Female;
Femur;
Femur Neck;
Humans;
Korea*;
Linear Models;
Logistic Models;
Nutrition Surveys;
Odds Ratio;
Osteoporosis;
Premenopause;
Spine
- From:Korean Journal of Family Medicine
2018;39(2):74-84
- CountryRepublic of Korea
- Language:English
-
Abstract:
BACKGROUND: We investigated the association between body composition, especially truncal or non-truncal fat mass (FM), and bone mineral density (BMD) in premenopausal women in Korea. METHODS: A cross-sectional study was performed using data from the Korea National Health and Nutrition Examination Survey IV and V (2008–2011). Total lean mass (LM), total FM (TFM), truncal FM, and non-truncal FM, and BMD of the total femur, femoral neck (FN), and lumbar spine were measured using dual-energy X-ray absorptiometry. The association between body composition and BMD was analyzed using multiple linear regression. The risk of low BMD according to quartiles of TFM, truncal FM, and non-truncal FM was calculated using logistic regression. Subgroup analysis according to body mass index was also performed. RESULTS: In 4,343 premenopausal women, total LM was positively associated with BMD regardless of weight adjustment. TFM, truncal FM, and non-truncal FM were inversely associated with BMD after adjusting for weight. Odds ratios (ORs) for low BMD and 95% confidence intervals (CIs) of the highest quartile of TFM, truncal FM, and non-truncal FM compared with the lowest quartile were calculated. The risk of low BMD of the FN was higher in the highest quartile of TFM (OR, 4.48; 95% CI, 1.11–18.01) and truncal FM (OR, 5.48; 95% CI, 1.75–17.20). Truncal FM and not-truncal FM had an inverse association with BMD in the non-obese and obese subgroups of women. CONCLUSION: Total LM has a protective effect on BMD and FM can have a detrimental effect on BMD besides its skeletal loading effect.
