Bone Health in Adrenal Disorders.
- Author:
Beom Jun KIM
1
;
Seung Hun LEE
;
Jung Min KOH
Author Information
- Publication Type:Review
- Keywords: Osteoporosis; Fracture; Pheochromocytoma; Hyperaldosteronism; Cushing syndrome
- MeSH: Cushing Syndrome; Hyperaldosteronism; Metabolism; Mortality; Osteoporosis; Pheochromocytoma
- From:Endocrinology and Metabolism 2018;33(1):1-8
- CountryRepublic of Korea
- Language:English
- Abstract: Secondary osteoporosis resulting from specific clinical disorders may be potentially reversible, and thus continuous efforts to find and adequately treat the secondary causes of skeletal fragility are critical to ameliorate fracture risk and to avoid unnecessary treatment with anti-osteoporotic drugs. Among the hyperfunctional adrenal masses, Cushing's syndrome, pheochromocytoma, and primary aldosteronism are receiving particularly great attention due to their high morbidity and mortality mainly by increasing cardiovascular risk. Interestingly, there is accumulating experimental and clinical evidence that adrenal hormones may have direct detrimental effects on bone metabolism as well. Thus, the present review discusses the possibility of adrenal disorders, especially focusing on pheochromocytoma and primary aldosteronism, as secondary causes of osteoporosis.
