Coronary Flow Reserve in Non-Infarcted Myocardium Predicts Long-Term Clinical Outcomes in Patients Undergoing Percutaneous Coronary Intervention.
10.3349/ymj.2018.59.2.252
- Author:
Rongchao CHENG
1
;
Xiaoming ZHU
;
Yunling LI
;
Xiuping BAI
;
Li XUE
;
Li WEI
Author Information
1. Department of Cardiology, the Forth Affiliated Hospital of Harbin Medical University, Harbin, China. chengrongchao@163.com
- Publication Type:Original Article
- Keywords:
Myocardial infarction;
microvascular dysfunction;
coronary flow reserve;
myocardial contrast echocardiography
- MeSH:
Aged;
Coronary Circulation/*physiology;
*Echocardiography;
Female;
Fractional Flow Reserve, Myocardial;
Humans;
Male;
Middle Aged;
Myocardial Infarction/diagnostic imaging/*physiopathology/*surgery;
Myocardial Perfusion Imaging;
Myocardium/*pathology;
*Percutaneous Coronary Intervention;
Proportional Hazards Models;
Treatment Outcome;
Ventricular Function, Left/*physiology
- From:Yonsei Medical Journal
2018;59(2):252-257
- CountryRepublic of Korea
- Language:English
-
Abstract:
PURPOSE: Coronary flow reserve (CFR) is recognized as an indicator of myocardial perfusion. The aim of this study was to assess the relationship between CFR in the non-infarcted myocardium and the incidence of major adverse cardiac events (MACEs). MATERIALS AND METHODS: 100 consecutive patients with acute myocardial infarction (AMI) undergoing percutaneous coronary intervention (PCI) were enrolled in the present study, and divided into MACE and non-MACE groups according to the incidence of 12-month MACEs. Left ventricular function and CFR were analyzed using two-dimensional echocardiography and myocardial contrast echocardiography at one week after PCI. Cardiac troponin I levels were assayed to estimate peak concentrations thereof. RESULTS: The MACE group was associated with lower CFR, compared to the non-MACE group (2.41 vs. 2.77, p < 0.001). In the multivariable model, CFR in the non-infarcted myocardium was an independent predictor of 12-month MACE (hazard ratio: 0.093, 95% confidence interval: 0.020–0.426, p=0.002) after adjustment for baseline demographic and clinical characteristics. CONCLUSION: CFR in the non-infarcted myocardium is a useful marker for predicting 12-month MACEs in patients with AMI undergoing primary PCI.
