Significance of Liver Biopsy in the Differential Diagnosis and Prognosis of Congenital Biliary Atresia and Infant Hepatitis Syndrome
- VernacularTitle:肝活检对先天性胆道闭锁与婴儿肝炎综合征鉴别及预后判断的意义
- Author:
Rui DU
1
;
Wen-Jing CHEN
;
Yu-Juan GUO
;
Hong-Yi GAO
Author Information
1. 广东省妇幼保健院病理科
- Keywords:
liver biopsy;
biliary atresia;
infantile hepatitis syndrome;
differential diagnosis;
prognosis
- From:
Journal of Sun Yat-sen University(Medical Sciences)
2018;39(3):438-442,封2
- CountryChina
- Language:Chinese
-
Abstract:
[Objective] To investigate the significance of liver biopsy in differential diagnosis and prognosis of congenital biliary atresia (CBA) and infant hepatitis syndrome (IHS).[Methods] Totally 77 children with congenital biliary atresia and 48 infants with hepatitis syndrome treated in Guangdong Women and Children Hospital from December 2012 to December 2016 were examined by liver biopsy and follow-up.Combined with immunohistochemistry and PAS staining,reticular fiber staining,Masson staining techniques,we make comparative analysis of both histopathological features and prognosis.[Results] The liver fibrosis grade,hepatic lobule inflammation activity staging,the degree of bile duct hyperplasia and the prognosis of CBA and IHS infants were statistically significant (P＜0.05).S2-S3-based liver fibrosis grading in infants with CBA,mainly in G2-G3 hepatic lobule inflammation staging,bile duct hyperplasia significantly;IHS infants with liver fibrosis grading as S0-S1,liver Slice inflammatory activity stage to G1-G2-based.The prognosis of infants with CBA was significantly worse than IHS,and the difference was statistically significant (P＜0.05).[Conclusion] The early liver biopsy of infants with congenital biliary atresia and infant hepatitis syndrome,combined with immunohistochemistry and PAS staining,reticular fiber staining,Masson staining techniques has important clinical significance to the differential diagnosis and prognosis of both.
