Far Upstream Element-Binding Protein 1 (Fubp1) Expression in Tongue Carcinoma and Its Relationship with the Clinicopathological Parameters and Prognosis
- VernacularTitle:人远端上游原件结合蛋白在舌癌组织中的表达及其与临床病理参数和预后的关系
- Author:
Yang CHEN
1
;
Jia-Meng LIU
;
Chong-Jin FENG
Author Information
1. 中山大学附属第一医院口腔科
- Keywords:
tongue squamous cell carcinoma;
FUBP1;
tumorigenesis;
proliferation;
prognosis
- From:
Journal of Sun Yat-sen University(Medical Sciences)
2018;39(3):393-399
- CountryChina
- Language:Chinese
-
Abstract:
[Objective] To investigate the far-upstream element (FUSE) binding protein 1 (FUBP1) expression in tongue squamous cell carcinoma (TSCC) and its adjacent normal tissues,to explore the role of FUBP1 in the initiation and development of TSCC and its clinical significance.[Methods] FUBP1 expression in TSCC tissues and its adjacent normal tissues was detected by immunohistochemistry,qRT-PCR and Western blot respectively.Statistical analysis was used to analyze the relationship between FUBP1 expression and clinical pathological parameters and prognosis.[Results] FUBP1 expression in TSCC tissues was higher than that in the corresponding adjacent normal tissues (P＜0.05);FUBP1 expression in TSCC tissues was higher in patients of advanced stage and with cervical lymph node metastasis (P＜0.001);The 5-year survival rate of FUBP1 over expression group was lower than that of FUBP1 low expression group (P=0.035);FUBP1 may be an independent predictor in patients with TSCC.[Conclusion] The high expression of FUBP1 in TSCC tissues is associated with poor prognosis in patients with TSCC,therefore,high expression of FUBP1 may promote the formation and development of TSCC,and become a index for prognosis in TSCC patients.
