Treatment of Recalcitrant Plantar Warts with 5-aminolevulinic Acid Photodynamic Therapy(ALA-PDT)after Preconditioning with Superpulse Carbon Dioxide Laser
- VernacularTitle:二氧化碳激光打孔预处理联合5-氨基酮戊酸光动力治疗难治性巨大跖疣
- Author:
Hai-Rong DAI
1
;
Hui ZHOU
;
Qiao-Fei LI
;
Hong-Zhong LING
;
Ji-Huang XIE
;
Yu-Hua LI
;
Guang-Ling CAO
Author Information
1. 中山大学附属第一医院皮肤科
- Keywords:
plantar wart;
photodynamic therapy;
carbon dioxide laser;
Human papilloma virus;
genotype
- From:
Journal of Sun Yat-sen University(Medical Sciences)
2018;39(1):152-156
- CountryChina
- Language:Chinese
-
Abstract:
[Objective]To investigate the efficacy and safety of ALA-PDT following CO2laser preconditioning for recal-citrant plantar warts.[Methods]Patients with recalcitrant plantar warts were enrolled in this study,and received ALA-PDT treatment following CO2laser preconditioning. Cure rate and side effects were observed.[Results]Twenty patients were en-rolled and 85%(17/20)showed complete clearance of plantar warts after one to three times of ALA-PDT. PDT treatment time was once in two patients(10%),twice in five patients(25%)while three times in 10 patients(50%).No infection or scar tissue was observed.Five(25%)patients were infected with one type of HPV,while 15(75%)patients with two or mul-tiple types of HPV. No difference was observed in complete clearance rate between patients with single or multiple HPV gen-otypes infection.[Conclusions]Superpulse carbon dioxide laser pretreatment enhanced the efficacy of ALA-PDT treatment on recalcitrant plantar warts.Further study is needed to determine the association of HPV genotype with outcome of recalci-trant plantar warts.
