Impact of Cerebral Blood Perfusion and Cognitive Function of Carotid Artery Stenting Combined with Medical Therapy for Patients with Severe Internal Carotid Stenosis
- VernacularTitle:颈内动脉支架置入术联合药物治疗对重度颈内动脉狭窄者脑血流灌注及认知功能的影响
- Author:
Li-Min YAN
1
;
Ming-Ming DAI
;
Hang YU
Author Information
1. 海南医学院第二附属医院神经内科
- Keywords:
severe internal carotid stenosis;
carotid artery stenting;
medical therapy;
cerebral blood flow perfusion;
cognitive function
- From:
Journal of Sun Yat-sen University(Medical Sciences)
2018;39(1):107-112
- CountryChina
- Language:Chinese
-
Abstract:
[objective]To study effect of cerebral blood perfusion and cognitive function of carotid artery stenting com-bined with medical therapy for patients with severe internal carotid stenosis.[Methods]124 patients with severe internal ca-rotid stenosis from June 2014 to June 2016 were divided into observed group and the treatment group,The treatment group given pure medical therapy,observation group given carotid artery stenting combined with medical therapy.One year follow-upr,cerebral blood flow perfusion,cognitive function,adverse events were compared between two groups.[Result]The ob-servation group rTTP,rMTT,rCBV,rCBF were significantly lower than treatment group(P<0.05,P<0.01);MMSE,MoCA score were significantly higher than treatment group(P<0.05);Vascular Occlusion,vascular restenosis,cerebral ischemic stroke,transient cerebral ischemia were significantly lower than treatment group(1.61% vs 11.29%,4.84% vs 19.35%, 1.61% vs 14.52%,4.84% vs 17.74,P<0.05).[Conclusion]Carotid artery stenting combined with medical therapy help to improve cerebral blood flow perfusion in patients with severe internal carotid stenosi,improve cognitive function,and pre-vent adverse events.
