Progress of drug resistance mechanism in checkpoint inhibitors
10.3760/cma.j.issn.1006-9801.2018.11.015
- VernacularTitle:免疫检查点抑制剂耐药机制研究进展
- Author:
Hanfei GUO
1
;
Lei QIAN
;
Jiuwei CUI
Author Information
1. 吉林大学第一医院肿瘤中心肿瘤科
- Keywords:
Neoplasms;
Immune checkpoint inhibitor;
Immunotherapy;
Immune resistance;
Tumor immune microenvironment
- From:
Cancer Research and Clinic
2018;30(11):780-784
- CountryChina
- Language:Chinese
-
Abstract:
Immune checkpoint signaling pathway mediates tumor immune escape through various mechanisms. In recent years, studies on immune checkpoint inhibitors have made great breakthroughs in various tumors. However, characteristics of the tumor cells, abnormal presentation of the antigens, functional gene mutations, tumor immune microenvironment, internal environment of patients and metabolic factors can all lead to primary or secondary resistance to immunotherapy. The exploration of the molecular mechanism and response strategy of immunotherapy is the key to further expand the beneficial population treated by immune checkpoint inhibitors and realize the accurate treatment.
