Prognostic value of combined examination of pre-operative carcinoembryonic antigen and CD44v6 for judging colorectal cancer
10.3760/cma.j.issn.1006-9801.2018.11.006
- VernacularTitle:术前联合检测癌胚抗原和CD44v6对判断结直肠癌患者预后的价值
- Author:
Bing YAN
1
;
Tao YANG
;
Tianhui XUE
;
Rui XU
;
Junhao YOU
Author Information
1. 解放军总医院海南医院肿瘤科
- Keywords:
Colorectal neoplasms;
Carcinoembryonic antigen;
Antigens;
CD44v6;
Neoplasm staging;
Prognosis
- From:
Cancer Research and Clinic
2018;30(11):744-748
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the prognostic value of combined examination of pre-operative carcinoembryonic antigen (CEA) and CD44v6 for colorectal cancer patients. Methods A total of 140 patients with complete clinical data pathologically diagnosed as colorectal cancer from December 2012 to December 2017 in Hainan Hospital of PLA General Hospital were enrolled. Finally, 69 validated cases excluding CEA (-) or CD44v6(-) patients were registered according to pre-operative CEA detection and immunohistochemistry results of CD44v6. Kaplan-Meier method was used to analyze the progression-free survival (PFS) time for single factors. Multiple-factor analysis was done by using Cox proportional hazard model. Results Sixty-nine patients included 29 cases of double positive and 40 cases of double negative in CEA and CD44v6. There were statistical significances of the expressions of double positive and double negative in patients with different gender, M stage, TNM stage. Double positive was more apparent in female (χ2 = 4.42, P= 0.04), presenting of metastasis (χ2=5.06, P=0.02) and advanced cases (χ2=4.38, P= 0.04); univariable analysis showed the N stage (P=0.00), M stage (P=0.00), TNM stage (P=0.00) and double positive/double negative in CEA and CD44v6 (P= 0.04) were likely to affect the PFS, however, multivariable analysis showed that N stage (HR= 0.15, 95 ％ CI: 0.03-0.86, P= 0.03), TNM stage (HR= 23.83, 95 ％ CI: 3.65-155.51, P=0.00) were the independent prognostic factors for PFS. PFS in double positive patients was shorter than that in double negative ones [24.0 months (3-84) vs. 31.0 months (8-94), P=0.04]. Conclusion Pre-operative combined examination of CEA and CD44v6 could be helpful in judging the prognosis for colorectal cancer patients.
