Progress of exosomes in multiple myeloma
10.3760/cma.j.issn.1006-9801.2018.10.019
- VernacularTitle:外泌体在多发性骨髓瘤中的研究进展
- Author:
Yu ZHANG
1
;
Shaoqing JU
;
Hui CONG
Author Information
1. 226001,南通大学附属医院医学检验科
- Keywords:
Exosomes;
Multiple myeloma;
Bone marrow microenvironment;
Bone mesenchymal stem cells;
Drug resistance
- From:
Cancer Research and Clinic
2018;30(10):717-720
- CountryChina
- Language:Chinese
-
Abstract:
Exosomes are small vesicles that are released from multivesicular bodies to the extracellular. They can carry proteins, lipids, DNA, miRNA and mRNA to the recipient cells, thereby altering the biological behavior of the recipient cells. In multiple myeloma (MM), exosomes could regulate the immune system, promote angiogenesis and the transformation of cancer-associated fibroblasts, interact with bone mesenchymal stem cells, enhance osteoclast activity, and induce MM resistance. Exosomes in the blood can be used as an early diagnostic marker for MM in order to provide a new diagnosis and treatment strategy for MM patients. This article summarizes the progress of the function, diagnosis and treatment of exosomes in MM.
