Progress of anti-tumor mechanisms of statins
10.3760/cma.j.issn.1006-9801.2018.10.017
- VernacularTitle:他汀类药物抗肿瘤作用机制的研究进展
- Author:
Yong ZHANG
1
;
Yaqian QIN
;
Duo YIN
Author Information
1. 中国医科大学附属盛京医院第二微创妇科
- Keywords:
Neoplasms;
Statins;
Anti-tumor effects;
Research
- From:
Cancer Research and Clinic
2018;30(10):710-713
- CountryChina
- Language:Chinese
-
Abstract:
Statins are a kind of hydroxymethylglutaryl-CoA (HMG-CoA) reductase inhibitors, which are commonly used to reduce cholesterol level, and prevent cardiovascular and cerebrovascular diseases. In recent years, more and more researches have showed that statins could inhibit angiogenesis through inhibiting the proliferation, invasion and metastasis of cancer cells, and could promote cancer cells apoptosis and synergetically enhance the effect of radiotherapy and chemotherapy to play a potential anti-tumor role. This paper reviews the domestic and foreign research progresses of the anti-tumor mechanisms of statins.
