Effect of human intestinal flora on tumorigenesis and therapeutic efficacy
10.3760/cma.j.issn.1006-9801.2018.07.015
- VernacularTitle:人体肠道菌群对肿瘤发生和治疗效果的影响
- Author:
Shen MENG
1
;
Wanqi ZHU
;
Ligang XING
Author Information
1. 250022,济南大学山东省医学科学院医学与生命科学学院
- Keywords:
Neoplasms;
Gut microbiota;
Mechanism;
Diagnosis
- From:
Cancer Research and Clinic
2018;30(7):493-497
- CountryChina
- Language:Chinese
-
Abstract:
The microorganism in human body is related to human health and disease,which plays a significant role in the exclusion of pathogen invading,participation of immune regulation and occurrence and development of the tumors.Studies have indicated that dysbacteriosis is often detected in cancer patients;especially,enteric dysbacteriosis can promote the occurrence and development of the tumors by influencing homeostatic balance of intestinal tract,gut metabolite and immunological function.Moreover,proportion detection of intestinal flora can be used as a non-invasive screening method and a diagnostic indicator for early detection of the malignant neoplasms.This review summarizes the recent studies on the associations of intestinal flora with human diseases and the possible mechanisms causing tumorigenesis,which may provide a novel research paradigm for cancer prevention and treatment.
