Progress of multi-cellular tumor spheroids culture technique for treatment of bladder cancer
10.3760/cma.j.issn.1006-9801.2018.07.014
- VernacularTitle:多细胞肿瘤球体培养技术在膀胱癌治疗中的研究进展
- Author:
Zhongyi MA
1
;
Hua ZHUANG
;
Cheng CHANG
;
Zhichun DONG
;
Junqian TIAN
Author Information
1. 730030,兰州大学第二医院泌尿系统疾病研究所甘肃省泌尿系统疾病研究重点实验室甘肃省泌尿系统疾病临床医学中心
- Keywords:
Urinary bladder neoplasms;
Three-dimensional cell culture;
Multi-cellular tumor spheroids;
Tumor microenvironment
- From:
Cancer Research and Clinic
2018;30(7):490-493
- CountryChina
- Language:Chinese
-
Abstract:
Cell culture is an important tool for biological research.To better understand the pathogenesis and therapeutic methods of the tumors,the three-dimensional cell culture is applied by more and more researchers to create a culture environment that closes to the tumor microoenvironment.Thanks to the advances in the tissue engineering technology,many kinds of models of the three-dimensional cell culture achieve wide accessibility.Compared with the traditional two-dimensional cell culture,the three-dimensional cell culture is better in simulating physiological features of the human histology and cells,including cell proliferation and differentiation,the interaction of cell to cell and cell to matrix.This paper reviews the progress of multi-cellular tumor spheroids (MCTS) culture technique of the three-dimensional cell culture for treatment of bladder cancer.
