Relationship between oncolytic viral therapy and tumor microenvironment or body immunity
10.3760/cma.j.issn.1006-9801.2018.06.017
- VernacularTitle:溶瘤病毒治疗与肿瘤微环境及机体免疫的关系
- Author:
Beibei ZENG
1
;
Wen ZHANG
;
Binlei LIU
;
Shangmei LIU
Author Information
1. 国家癌症中心 国家肿瘤临床医学研究中心 中国医学科学院北京协和医学院肿瘤医院病理科
- Keywords:
Oncolytic viruses;
Tumor microenvironment;
Immunotherapy
- From:
Cancer Research and Clinic
2018;30(6):423-425
- CountryChina
- Language:Chinese
-
Abstract:
The interaction between oncolytic virus (OV) and the tumor microenvironment or body immune system is critical to the outcome of antitumor therapy. The antitumor mechanism of OV is complex, which involves direct cytotoxic effects, immunogenicity change in tumor microenvironment, the role of tumor vasculature, and activating of the antitumor immunity response, to reach the goal of killing the tumor cells infected or uninfected, and confirming the continous favorable effects.
