Association between family history of malignant neoplasms and clinicopathological features in patients with colorectal cancer
10.3760/cma.j.issn.1006-9801.2018.05.008
- VernacularTitle:恶性肿瘤家族史与结直肠癌患者临床病理特征的关系
- Author:
Tianyuan LI
1
;
Shuning XU
;
Ke LI
;
Danyang LI
;
Lei QIAO
;
Ying LIU
Author Information
1. 450008,郑州大学附属肿瘤医院 河南省肿瘤医院消化内科
- Keywords:
Colorectal neoplasms;
Family history of malignant neoplasms;
Clinicopathological characteristics;
Risk factors
- From:
Cancer Research and Clinic
2018;30(5):319-323
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the association between clinicopathological characteristics and familial history of malignant neoplasms (MN-FH) in patients with colorectal cancer. Methods The clinical data of 652 cancer patients in Zhengzhou University Affiliated Cancer Hospital from December 2014 to December 2015 were analyzed retrospectively. Patients were grouped based on with or without MN-FH. The clinical and pathological features of the patients were analyzed by χ 2test. Results One hundred and thirty cases (19.9 %) of colorectal cancer had MN-FH. Compared with NO MN-FH group, MN-FH group had the features of low differentiation degree, late clinical stage, deep infiltration, and also prone to lymph node metastasis and distant metastasis, associated with cancer nodules, vascular thrombosis, nerve invasion, multiple primary tumor, MSI-H (χ 2values were 30.825, 12.270, 12.122, 8.502, 53.969, 4.502, 12.861, 11.680, 6.272, 17.460, all P < 0.05). Conclusions Colorectal cancer patients with MN-FH has high malignant degree,the early diagnosis and treatment are the key to survival of patients with MN-FH.
