Clinical study of intravesical instillation with Sufuning lotion for prevention of postoperative recurrence of bladder cancer
10.3760/cma.j.issn.1006-9801.2018.02.011
- VernacularTitle:苏复宁洗液膀胱灌注预防膀胱癌术后复发的临床研究
- Author:
Xuebing HAN
1
;
Jianwu LIU
;
Xihua YANG
;
Dongzi PANG
;
Zhibin LI
;
Bin WANG
;
Jiwen SONG
;
Huiqing CHEN
;
Liansheng REN
;
Zhenguo MI
Author Information
1. 山西省肿瘤医院泌尿外科
- Keywords:
Urinary bladder neoplasms;
Chemotherapy;
cancer;
regional perfusion;
Recurrence;
Sufuning lotion
- From:
Cancer Research and Clinic
2018;30(2):116-119
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the efficacy and safety of intravesical instillation with Sufuning (SFN) lotion for prevention of postoperative recurrence of bladder cancer. Methods A total of 240 bladder cancer patients who were diagnosed as bladder cancer and accepted trans-urethral resection of bladder tumor from January 2010 to June 2016 in Shanxi Provincial Cancer Hospital were randomly divided into the experimental group (120 cases) and the control group (120 cases) according to the envelope method. The patients in the experimental group were treated with SFN lotion for immediate intravesical instillation(250 mg for once), and the patients in the control group were treated with pirarubicin (THP) for immediate intravesical instillation (30 mg for once). The patients of two groups were treated with intravesical chemotherapy once a week for 8 times, and the chemotherapy was performed once a month for 1 year. The recurrence rate, progression-free survival (PFS) rate, overall survival (OS) rate and recent side effects were compared between the two groups. Results The patients were followed up for 6 to 60 months. The median follow-up time was 36.5 months.In the experimental group,6 patients were lost and 8 patients were lost in the control group.The experimental group, the total recurrence rate was 26.3 % (30/114). The control group, the overall recurrence rate was 25.0 % (28/112) (χ2= 0.142, P = 0.781). Five years of PFS rate in the experimental group and the control group was 73.7 % (84/114) and 75.0 % (84/112) respectively, and there was no significant difference between the two groups (χ2= 2.011, P= 0.615). Five years of OS rate in the experimental group and the control group was 95.6 % and 92.9 % respectively, and there was no significant difference between the two groups (χ 2= 1.611, P= 0.425). The major side effects included chemical cystitis and hematuria. The incidence of chemical cystitis and hematuria in the experimental group was significantly lower than that in the control group(χ2=5.991,P=0.018;χ2=4.925,P=0.036).There was a statistically significant difference of the hematological side effects (blood routine changes) between the two groups (χ 2= 4.891, P= 0.032). Conclusion It is safe and effective for intravesical instillation of SFN lotion to prevent the recurrence of bladder cancer.
