Clinical observation of nanoparticle albumin-bound paclitaxel monotherapy in the three-line treatment of elderly patients with advanced non-small cell lung cancer
10.3760/cma.j.issn.1006-9801.2018.01.012
- VernacularTitle:白蛋白结合型紫杉醇单药三线治疗老年晚期非小细胞肺癌患者临床观察
- Author:
Jianjun XIAO
1
;
Wenjing DONG
;
Jiewen PENG
;
Xiaomei JIANG
;
Zhaofeng YIN
;
Huifen LI
Author Information
1. 528403,广东省中山市人民医院化疗科
- Keywords:
Carcinoma;
non-small-cell lung;
Nanoparticle albumin-bound paclitaxel;
Drug therapy;
Elderly
- From:
Cancer Research and Clinic
2018;30(1):57-59
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the clinical efficacy and safety of nanoparticle albumin-bound paclitaxel (Nab-P) in the treatment of advanced non-small cell lung cancer (NSCLC). Methods Fifty-six over 65 years old patients with advanced NSCLC treated with Nab-P monotherapy in department of chemotherapy of the People's Hospital of Zhongshan City from January 2014 to January 2017 were analyzed retrospectively. The chemotherapy regimen was Nab-P 260 mg/m2, on d1 or d1 + d8, every 21 day for a cycle, imaging examination was made for efficacy evaluation after every 2 cycles. Results All 56 patients had been evaluated for efficacy, and received a total of 186 cycles of chemotherapy. All patients had been completed 2 cycles or more than 2 cycles of chemotherapy, and the median number of chemotherapy cycles was 3. The treatment response rate (RR) was 25.0 ％ and the disease control rate (DCR) was 76.8 ％. The median progression free survival (PFS) time was 4.7 months. The main adverse reactions were neutropenia, nausea and vomiting, fatigue and peripheral nerve toxicity. However, the vast majorities of adverse reactions were grade 1-2, and can be improved after treatment. Conclusions Nab-P is effective in the treatment of advanced NSCLC in elderly patients. The adverse reactions are mild and tolerant, and it is worthy to be popularized.
