Expressions of Th17 lymphocytes and interleukin-17 in peripheral blood of patients with non-small cell lung cancer and their clinical significances
10.3760/cma.j.issn.1006-9801.2018.01.006
- VernacularTitle:非小细胞肺癌患者外周血Th17淋巴细胞和白细胞介素17的表达及其意义
- Author:
Gang CHEN
1
;
Jingjing DUAN
;
Wen SU
;
Yanfeng WANG
;
Junning SUN
;
Xiaoxiang DU
;
Junsheng LI
;
Peigang ZHANG
;
Shiping GUO
Author Information
1. 山西省肿瘤医院胸外二病区
- Keywords:
Carcinoma;
non-small-cell lung;
Th17 cells;
Interleukin-17
- From:
Cancer Research and Clinic
2018;30(1):29-33
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expressions of Th17 lymphocytes and interleukin-17 (IL-17) in peripheral blood of patients with non-small cell lung cancer (NSCLC) and its clinical significance. Methods Sixty patients with primary and untreated NSCLC were enrolled and designed as experimental group, at the same time, 60 healthy volunteers were collected as control group. Flow cytometry (FCM) was used to detect the level of Th17 lymphocytes. Enzyme linked immunosorbent assay (ELISA) was used for detecting the level of IL-17. The relationship between the expression levels of Th17 and IL-17 in peripheral blood and clinicopathological features was compared between the two groups. Results The peripheral blood levels of Th17 lymphocytes and IL-17 in the experimental group [(1.7±1.2) ％, (8.3±2.5) pg/ml] were higher than those in the control group [(0.9 ±0.6) ％, (5.4 ±1.2) pg/ml] (P< 0.05). The peripheral blood expression of Th17 lymphocytes and IL-17 in patients with smoking history [(1.8±1.2) ％, (8.8±3.7) pg/ml] were higher than those in patients without smoking history [(1.6±1.2)％, (8.0±2.2) pg/ml], and the peripheral blood expression of Th17 lymphocytes and IL-17 were higher in patients with squamous-cell carcinoma [(1.8 ±1.2) ％, (9.4 ±4.7) pg/ml] than those in patients with adenocarcinoma [(1.6±1.1) ％, (7.3±3.9) pg/ml], furthermore, they were also higher in patients with stage Ⅲ-Ⅳ than those in patients with stage Ⅰ-Ⅱ (P < 0.05). Conclusion Th17 lymphocytes and IL-17 play certain roles in the occurrence and progression of NSCLC.
