Effect of Latanoprost on the Cultured Human Uveal Melanocytes.
- Author:
Eung Cheol KIM
1
;
Jae Woo KIM
Author Information
1. Department of Ophthalmology, Catholic University of Daegu, Daegu, Korea.
- Publication Type:Original Article
- Keywords:
Hydrocortisone;
Indomethacine;
Latanoprost;
Melanocyte
- MeSH:
Dinoprost;
Humans*;
Hydrocortisone;
Indomethacin;
Melanins;
Melanocytes*
- From:Journal of the Korean Ophthalmological Society
2001;42(6):893-897
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: To investigate the effect of latanoprost on the melanogenesis and endogenous PG release. METHODS: Primarily cultured uveal human melanocytes were exposed to 0.1 micrometer, 1 micrometer, and 10 micrometer of PhXA85 and also co-exposured with 1 micrometer of indomethacine or hydrocortisone, the melanin content of each melanocyte was measured with spectrophotometer after 1 week. RESULTS: After 1 week, the melanin content of each melanocyte was increased with 1 micrometer, 10 micrometer of PhXA85(p<0.05). After co-exposure with indomethacine or hydrocortisone, the amount of increased melanin content was less than that of PhXA85 alone and statistically significant with 10 micrometer of PhXA85(p<0.05). CONCLUSIONS: These results show that PhXA85 stimulates melanogenesis of cultured human uveal mela-nocytes and also suggests the possibility of exogenous PGF2 alpha-induced release of endogenous prostaglandin.
