Morphologic Changes of Anterior Chamber Angle and Trabecular Meshwork According to Embryonic Age in Human Fetal Eyes.
- Author:
Jou Weon YOUN
1
;
Myung Kyoo KO
;
Je Geun CHI
Author Information
1. Department of Ophthalmology, College of Medicine, Hanyang University, Seoul, Korea.
- Publication Type:Original Article
- Keywords:
Congenital glaucoma;
Fetus;
Iridocorneal angle;
Development;
Trabecular meshwork
- MeSH:
Anterior Chamber*;
Aqueous Humor;
Drainage;
Fetus;
Gestational Age;
Glaucoma;
Humans*;
Microscopy;
Trabecular Meshwork*
- From:Journal of the Korean Ophthalmological Society
2001;42(6):898-902
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: To investigate the morphologic changes of anterior chamber angle and trabecular meshwork during development in human fetal eyes, 77 eyes was enrolled in this study. METHODS: The sequential development of iridocorneal angle and trabecular meshwork were examined using light microscopy in 77 eyes with a gestational age ranged from 7 to 40 weeks. RESULTS: It was found that the presence of openings in the anterior chamber angle lining and aqueous humor drainage was effective by 20~22 weeks of fetal life and intercellular gaps become larger and more frequent as development progresses. During the gestational age(28~30 week), the anterior ahamber was located at the middle of the trabecular meshwork. During the gestational age(32~38 week), the intertra-becular space was widen with the apparent presence of the Schlemm's canal. CONCLUSIONS: The arrest or abnormal differetiation during the gestational period may cause the dysfunction of aqueous humor outflow, to develop congenital glaucoma.
