Effect of Amniotic Membrane Transplantation on Tissue Adhesion after Strabismus Surgery in Rabbits.
- Author:
Jae Wook CHUNG
1
;
Sang Jin KIM
;
Jae Hong AHN
;
Hyun Yi YIM
Author Information
1. Department of Ophthalmology, Ajou University School of Medicine, Suwon, Korea.
- Publication Type:Original Article
- Keywords:
Amniotic membrane;
Postopertive adhesion;
Strabismus surgery
- MeSH:
Amnion*;
Humans;
Inflammation;
Muscles;
Rabbits*;
Strabismus*;
Tissue Adhesions*
- From:Journal of the Korean Ophthalmological Society
2001;42(6):903-910
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: The purpose of the experiment with the rabbit was to evaluate the effect of human amniotic membrane transplantation in the extraocular muscle surgery area after the operation. METHODS: Five millimeters resection of both superior rectus muscles was performed in eight rabbits. The left eye was served as a control, and the right eye was covered with human amniotic membrane at the site where the operation was performed. Each rabbit was graded according to the degree of adhesion. A histological comparison was done after enucleation. RESULTS: At one week after the operation, it was discovered that the inflammation of the human amniotic membrane transplantation site was suppressed, but at two weeks the human amniotic membrane transplantation site was significantly inflamed. However, the inflammation decreased at six weeks. CONCLUSIONS: This study shows that strabismus surgery with transplantation of human amniotic membrane may reduce postoperative inflammation and adhesion in strabismus surgery after one week. However, after two weeks the inflammation will increase and produce more postoperative adhesion. After six weeks there was no significant inflammation in comparison to the control group.
