Combined ablative fractional Er ∶ YAG laser and 10％ ALA-PDT in treatment of refractory verruca plana
10.3760/cma.j.issn.1671-0290.2017.06.010
- VernacularTitle:Er∶ YAG点阵激光联合10％5-氨基酮戊酸光动力治疗顽固性扁平疣的疗效
- Author:
Li TANG
1
;
Lin LIN
;
Yan XIAO
;
Aiai XIA
;
Xichuan YANG
;
Zhiqiang SONG
;
Rui YIN
Author Information
1. 第三军医大学西南医院皮肤科
- Keywords:
Fractional ablative laser;
Photodynamic therapy;
Verruca plana;
Aminolevulinic acid
- From:
Chinese Journal of Medical Aesthetics and Cosmetology
2017;23(6):393-395
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the efficacy of combined therapies of ablative fractional Er ∶YAG laser (2,940 nm) and ALA-PDT on refractory verruca plana.Methods 120 cases of refractory verruca plana patients were randomly divided into two groups:60 cases in the control group and 60 cases in the experimental group.The control group used 10％ ALA-PDT with LED irradiation of a power density 70 of mW/cm2 at a distance of 20 cm,which lasted for 20 min each time.The experimental group was treated with ablative fractional Er ∶ YAG laser (2,940 nm) first with the fluence of 500P/cm2 and short pulse duration,and then treated 10％ ALA-PDT as mentioned before.Every patient was treated twice at two-week intervals.Three independent investigators evaluated subject outcomes at 3 months post-treatment including efficacy and side-effects.Results The effective rate of the experimental group was 86.44 ％ at 3 months post-treatment after one to two times.Meanwhile,the control group was 59.65 ％.The clinical outcome of experimental group was better than the control group.There was significant difference between the two groups (P＜0.05).The recurrent rate of experimental group was 3.39％ and 12.30％ in control group.There was significant difference between the two groups (P＜0.05).There were no obvious side-effects in both groups.Conclusions Ablative fractional laser with low fluence promotes the transdermal absorption of ALA and enhances the efficacy of PDT.
