Changes of serum neutrophil chemotactic activity(NCA) and myeloperoxidase(MPO) level following lysine-aspirin(L-ASA) bronchoprovocation test in aspirin-sensitive asthmatic patients.
- Author:
Sun Sin KIM
;
Hee Yeon KIM
;
Dong Ho NAM
;
Ki Such JUNG
;
Hae Sim PARK
- Publication Type:Original Article
- Keywords:
serurn neutrophil chemotactic activity;
mast cell;
aspirin-sensitive asthma
- MeSH:
Asthma;
Bronchoconstriction;
Humans;
Inhalation;
Mast Cells;
Neutrophil Activation;
Neutrophil Infiltration;
Neutrophils*
- From:Journal of Asthma, Allergy and Clinical Immunology
1999;19(2):181-187
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND: There have been few reports suggesting involvement of mast cell and neutrophil to induce bronchoconstriction in aspirin-sensitive asthrna. OBJECTIVE: To evaluate mast cell and neutrophil activation in pathogenesis of aspirin-sensitive asthma. MATERIAL AND METHOD: We observed changes of serum NCA and MPO levels during L-ASA bronchoprovocation test in 14 subjects with aspirin-sensitive asthma. RESULTS: Serum NCA was significantly increased at 30 min(p=0.01) after the inhalation of L-ASA and then, no significant changes were noted at 240 min (p=0.14). NCA was significantly higher in subjects with late asthmatic responses than in those without it (p=0.04). Serum MPO level tended to increase at 30 min with no statistical significance (p=0.08), and then it significantly decreased at 240 min (p=0.05). There was no significant correlation between serum NCA and MPO level (r=0.22, p=0.58). CONCLUSION: These results support the view that NCA derived from mast cell may contribute to neutrophil recruitment into the airway in aspirin-sensitive asthmatic patients.
