The synergistic mechanisms of oxidized phospholipids and lipoprotein-associated phospholipase A2 associated with Lp ( a ) in promoting atherosclerosis
10.3760/cma.j.issn.1009-9158.2018.11.022
- VernacularTitle:脂蛋白相关磷脂酶A2水解脂蛋白(a)连接的氧化磷脂促进动脉粥样硬化发生发展作用机制的研究进展
- Author:
Hangqi LIU
1
;
Mei JIA
Author Information
1. 100044,北京大学人民医院检验科
- Keywords:
Atherosclerosis;
Cardiovascular diseases;
1-Alkyl-2-acetylglycerophosphocholine esterase;
Lipoprotein ( a);
Oxidation-reduction;
Phospholipids;
Inflammation
- From:
Chinese Journal of Laboratory Medicine
2018;41(11):897-900
- CountryChina
- Language:Chinese
-
Abstract:
Lipoprotein ( a ) [ Lp ( a ) ] is considered a causal risk factor for the formation and development of atherosclerosis ( AS).High plasma levels of Lp ( a) is recognized as a predictor of coronary heart disease. However, the pathogenic mechanisms of Lp ( a ) are still unknown. Recent studies demonstrated that a key role in the proatherogenic effects of Lp ( a ) may be linked to its oxidized phospholipids ( OxPL) content.Lipoprotein-associated phospholipase A 2 ( Lp-PLA2 ) is another important factor in Lp( a) functionality.OxPL are hydrolyzed by Lp-PLA2 into lysophosphatidylcholine ( lyso-PC) and oxidized free fatty acid(OxFFA), which are important inflammatory factors on promoting the occurrence and development of AS.The present review article describes Lp-PLA2 hydrolyzing OxPL associated with Lp (a). The process induces inflammatory factors , which promote development of AS .OxPL and Lp-PLA2 can be used as new targets of cardiovascular diseases , which have clinical application value to predict potential cardiovascular diseases .
