Are Churg-Strauss syndrome and idiopathic hypereosinophilic syndrome in the same spectrum?: A case with overlapping features.
- Author:
Yoon Suk CHANG
;
Jee Wong SON
;
Sang Rock LEE
;
Jae Kyung PARK
;
Sang Heon CHO
;
Kyung Up MIN
;
You Young KIM
- Publication Type:Case Report
- Keywords:
Churg-Strauss sydrome;
hypereosinophilic syndrome;
overlap syndrome;
vasculitis
- MeSH:
Adult;
Asthma;
Biopsy;
Churg-Strauss Syndrome*;
Cyclophosphamide;
Diagnosis, Differential;
Diuretics;
Eosinophilia;
Eosinophils;
Female;
Heart Failure;
Humans;
Hypereosinophilic Syndrome*;
Necrosis;
Prednisolone;
Skin;
Systemic Vasculitis;
Vasculitis
- From:Journal of Asthma, Allergy and Clinical Immunology
1999;19(2):208-218
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Sometimes, it is difficult to distinguish Churg-Strauss syndrome from idiopathic hypereosinophilic syndrome and there may be overlap syndrome in the differential diagnosis of systemic vasculitis with hypereosinophilia. Recently, we experienced a 42-year-old female patient who presented signs and symptoms of cardiac failure and neuropathy with peripheral hypereosinophilia. She had no history of asthma. She had erythematous skin lesions and distal digit necrosis. The cause of hypereosinophilia could not be identified. Skin and nerve biopsy revealed vasculitis with eosinophilic infiltration. Cardiac failure improved dramatically with steroid, inotropics and diuretics. Other symptoms including digital necrosis also improved. During steroid, tapering peripheral eosinophilia recurred. For maintenance therapy, we added daily cyclophosphamide to every-other-day prednisolone therapy. We report the case with a review of the literature.
