The function of interleukin-22 in the development of malignant tumors of digestive system
10.3760/cma.j.issn.1009-9158.2018.10.005
- VernacularTitle:白介素22在消化系统恶性肿瘤发生发展中的作用
- Author:
Mengyao SUN
1
;
Qiuxue WU
;
Si CAI
;
Sheng YANG
;
Qingfeng TANG
Author Information
1. 200062,上海中医药大学附属普陀医院检验科、中心实验室
- Keywords:
Digestive system neoplasms;
Interleukins;
Biomarkers;
tumor
- From:
Chinese Journal of Laboratory Medicine
2018;41(10):720-723
- CountryChina
- Language:Chinese
-
Abstract:
Malignant tumors of the digestive system , with high morbidity and mortality rate , are insidious at the onset and lack of effective treatments so far .Interleukin-22 (IL-22) is one of the members of the IL-10 cytokine family discovered in recent years and was originally called IL-10-associated T cell differentiation inducing factor (IL-TIF).IL-22 expression is elevated in various digestive system malignant tumors, and increased IL-22 expression is associated with tumor progression and poor prognosis .Studies on the molecular mechanism revealed that IL-22 initiates a series of downstream signaling pathways such as JAK/STAT and MAPK, by acting on the IL-22 receptor, inducing tumorigenesis.IL-22 is expected to be a novel diagnostic biomarker and therapeutic target of digestive system malignant tumor .
