Research advance in Enterobacteria ceaebacteria resistant to polymyxins
10.3760/cma.j.issn.1009-9158.2018.09.012
- VernacularTitle:临床常见肠杆菌科细菌对多黏菌素的耐药机制研究进展
- Author:
Xingyan MA
1
;
Cha CHEN
;
Bin HUANG
Author Information
1. 中山大学附属第一医院检验医学部
- Keywords:
Enterobacteriaceae;
Polymyxins;
Drug resistance,bacterial
- From:
Chinese Journal of Laboratory Medicine
2018;41(9):685-691
- CountryChina
- Language:Chinese
-
Abstract:
In order to deal with the increasing number of multidrug resistant Enterobacteriaceae , polymyxins were re-introduced into clinical practice .The resistance of polymyxins had gained global attention.In addition to chromosomal mediated drug resistance , a new plasmid-mediated colistin-resistance gene mcr-1 made transferation of polymyxins resistance more easily .Here, the mechanisms of chromosome mediated polymyxin resistance and plasmide-mediated drug resistance , including the distribution , prevalence, transfer mechanism, and genetic environments of mcr-1, current methods for polymyxins susceptibility testing methods and novel qualitative detection techniques were reviewed to provide information to cope with the growing problem of bacterial drug resistance .