The clinical significance of HCV antibody S/CO values in the diagnosis of active HCV infection in cancer patients
10.3760/cma.j.issn.1009-9158.2018.06.007
- VernacularTitle:肿瘤患者丙肝病毒抗体结果在HCV现症感染诊断中的临床价值
- Author:
Minjie WANG
1
;
Binbin HAN
;
Linkun SUN
;
Xuexiang LI
;
Xiaohong HAN
;
Wei CUI
Author Information
1. 100021,国家癌症中心/中国医学科学院北京协和医学院肿瘤医院检验科
- Keywords:
Liver neoplasms;
Hepatitis C antibodies;
RNA,viral;
ROC curve
- From:
Chinese Journal of Laboratory Medicine
2018;41(6):442-445
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the clinical significance of HCV antibody S /CO values in active HCV infection diagnosis in cancer patients .Methods 390 cancer patients were enrolled from Cancer Hospital Chinese Academy of Medical Sciences between January 2013 and April 2015.All of the cancer patients had pathological diagnosis , including 240 males and 150 females, aged from 25 to 83 years old. HCV antibody and HCV RNA levels were detected using the Abbott i 2000 immunity analyzer and Roche LC480 real-time fluorescent quantitative PCR machine , respectively.The relationship between HCV antibody S/CO value and RNA level was analyzed in the group of HCC and non-HCC patients.Results There were obvious statistical differences in age (P＝0.004), gender (P＜0.001) and HCV antibody levels (P＜0.001) between the group of HCC and non-HCC patients.There was no statistical difference in distribution of RNA positive rate between the two groups (P＝0.528).Using ROC curve analysis, the best cut-off value to diagnose active HCV infection in cancer patients is 10.0 with sensitivity 97.6%and specificity 81.3%. According to the results of the ROC curve , the cut-off was 11.4 and 10.4 in HCC and non-HCC patients respectively.Conclusion The best cut-off value to diagnose active HCV infection in cancer patients is 10.0, either in HCC or in non-HCC.
