System assessment of the correlation between vaginal microecological balance disorders and infertility

VernacularTitle:阴道微生态失调与不孕症相关性的系统评价
Author: Fan HE ¹ ; Chanyu ZHANG ; Sanglin LI ; Lisi WANG ; Li′na HU
Author Information

1. 400010,重庆医科大学附属第二医院妇产科生殖医学中心
Keywords: Infertility,female; Vagina; Microbiota; Dysbiosis; Meta-analysis
From: Chinese Journal of Laboratory Medicine 2018;41(4):281-286
CountryChina
Language:Chinese
Abstract: Objective To evaluate the association of vaginal dysbiosis and infertility.Methods Cohort studies, case-control studies and cross-sectional studies were searched in electronic databases, including MEDLINE,EMBASE and SinoMed(from inception to October 2017);in addition, the reference lists of included studies and similar reviews were handsearched.These studies investigating the correlation between vaginal dysbiosis and infertility were included.The Meta-Analysis was performed by RevMan 5.3 software.Results 1 724 records were retrieved by the search; from those,9 cross-sectional studies were included,comprising 3 367 participants(1 702 in infertility group and 1 665 in control group).The likelihood of vaginal dysbiosis in infertility group is higher than that of control group[OR=3.15,95% CI (1.57,6.32), P=0.001].Conclusions The available evidence suggests that vaginal dysbiosis was associated with the incidence of infertility.However, further case-control studies or cohort studies are required to confirm or refute these findings.(Chin J Lab Med,2018,41:281-286)