Single cell-based molecular detecting technologies in preimplantation genetic testing

VernacularTitle:基于单细胞的分子技术在胚胎植入前遗传学检测中的应用
Author: Wenyin HE ¹ ; Yong XIA
Author Information

1. 510150,广州医科大学附属第三医院检验科
Keywords: Preimplantation genetic testing; Embryonic biopsy; Whole genome amplification; Next generation sequencing
From: Chinese Journal of Laboratory Medicine 2018;41(4):270-274
CountryChina
Language:Chinese
Abstract: Since the first report of preimplantation genetic diagnosis success in clinical in 1989,it is technological development that has been the driving force of preimplantation genetic testing(PGT).As the early stage prenatal diagnosis, PGT is used in the setting of assisted reproduction to differentiate the genetically normal embryos from pathogenic mutations or chromosomal anomalies in order to increase the rates of fruitful pregnancy.PGT involves technologies of assisted reproduction, molecular detection and genetic counseling.The aim of this review is to, from the perspective of laboratory medicine, summarize the utilization and progress of molecular strategies in the field of PGT,and explore its future development.(Chin J Lab Med,2018,41:270-274)