Correlation between ultrasonographic features of thyroid nodules and BRAFV600Emutation
10.3877/cma.j.issn.1672-6448.2017.12.008
- VernacularTitle:甲状腺结节声像图特征与BRAFV600E基因突变的相关性研究
- Author:
Ming YANG
1
;
Yukun LUO
;
Yan ZHANG
;
Mingbo ZHANG
;
Rong WU
;
Jing WEN
;
Fang XIE
;
Ying ZHANG
;
Jie LI
Author Information
1. 解放军总医院超声科
- Keywords:
Thyroid nodule;
Gene mutations;
Ultrasonography
- From:
Chinese Journal of Medical Ultrasound (Electronic Edition)
2017;14(12):914-918
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the correlation between ultrasonographic features of thyroid nodule and BRAFV600Emutation. Methods A total of 179 patients with 194 suspicious throid nodules were included in this study. They underwent ultrasound, biopsy, pathology and BRAFV600Emutation examination between October 2015 and February 2016 at Chinese PLA General Hospital. The size of nodules were (1.1±0.8) cm. The size, echo, boundary, shape aspect ratio, calcification and capsular invasion of nodules were investigated. The correlation between ultrasonographic features of thyroid nodule and BRAFV600Emutation analyzed by chis-square test and Logistic Regression analysis using statistical data as independent variable, BRAFV600Emutation as dependent variable. Results There were significant different in nodule′s ratio, boundary, capsular invasion characteristic between the BRAFV600Epositive group and the BRAFV600Enegative group(χ2=11.174,45.517,11.046,all P < 0.05),and these signs are possibly associated with BRAFV600Emutation by logistic regression model analysis(OR=2.276,95%CI:1.117-4.638, P < 0.05; OR=8.412, 95%CI: 3.836-18.448,P < 0.001; OR=2.582, 95%CI: 1.138-5.860,P < 0.05). Conclusions The ratio, boundary, capsular invasion characteristic of thyroid nodules are possibly associated with BRAFV600Emutation. These signs can be used to predict BRAFV600Emutation and facilitate subsequent treatment for such nodules.
