Advances of stem cell transplantation in the treatment of retinal degeneration

VernacularTitle:干细胞移植治疗视网膜退行性病变的研究进展
Author: Na SUN ¹ ; Ping GU ; Jing JI
Author Information

1. 200011,上海交通大学医学院附属第九人民医院眼科
Keywords: Retinal diseases/therapy; Embryonic stem cells; Adult stem cells; Review
From: Chinese Journal of Ocular Fundus Diseases 2018;34(6):613-617
CountryChina
Language:Chinese
Abstract: Retinal degeneration mainly include age-related macular degeneration,retinitispigmentosa and Stargardt's disease.Although its expression is slightly different,its pathogenesis is photoreceptor cells and/or retinal pigment epithelial (RPE) cel 1 damage or degeneration.Because of the 1 ack of self-repairing and renewal of retinal photoreceptor cells and RPE cells,cell replacement therapy is one of the most effective methods for treating such diseases.The stem cells currently used for the treatment of retinal degeneration include embryonicstem cells (ESC) and various adult stem cells,such as retinal stem cells (RSC),induced pluripotent stem cells (iPSC).and mesenchymal stem cells (MSC).Understanding the currentbasic and clinical application progress ofESC,iPSC,RSC,MSC can provide a new idea for the treatment of retinal degeneration.