Research progress of different types of stem cells in the application of diabetic retinopathy
10.3760/cma.j.issn.1005-1015.2018.04.026
- VernacularTitle:不同类型的干细胞在糖尿病视网膜病变中的作用研究进展
- Author:
Bowen CAO
1
;
Xuxia MENG
Author Information
1. 266500,青岛大学附属医院眼科
- Keywords:
Diabetic retinopathy/etiology;
Diabetic retinopathy/therapy;
Mesenchymal stem cells;
Embryonic stem cells;
Review
- From:
Chinese Journal of Ocular Fundus Diseases
2018;34(4):415-421
- CountryChina
- Language:Chinese
-
Abstract:
Diabetic retinopathy is a serious complication of diabetes and is the leading cause of blindness in people with diabetes.At present,there are many views on the pathogenesis of diabetic retinopathy,including the changes of retinal microenvironment caused by high glucose,the formation of advanced glycation end products,oxidative stress injury,inflammatory reaction and angiogenesis factor.These mechanisms produce a common pathway that leads to retinal degeneration and microvascular injury in the retina.In recent years,cell regeneration therapy plays an increasingly important role in the process of repairing diseases.Different types of stem cells have neurological and vascular protection for the retina,but the focus of the target is different.It has been reported that stem cells can regulate the retinal microenvironment and protect the retinal nerve cells by paracrine production,and can also reduce immune damage through potential immunoregulation,and can also differentiate into damaged cells by regenerative function.Combined with the above characteristics,stem cells show the potential for the repair of diabetic retinopathy,this stem cell-based regenerative therapy for clinical application provides a pre-based evident.However,in the process of stem cell transplantation,homogeneity of stem cells,cell delivery,effective homing and transplantation to damaged tissue is still a problem of cell therapy.
