Advanced studies on the role of Slit2-Robo signaling in angiogenesis of fundus oculi and some other organs
10.3760/cma.j.issn.1005-1015.2018.03.026
- VernacularTitle:Slit2-Robo信号在眼底及全身血管生成的研究进展
- Author:
Shaoqiu JIANG
1
;
Danning LIU
;
Xiyuan ZHOU
Author Information
1. 400010,重庆医科大学附属第二医院眼科
- Keywords:
Slit2-Robosignaling;
Fundusoculi;
Angiogenesis;
Neovascularization,pathologic;
Review
- From:
Chinese Journal of Ocular Fundus Diseases
2018;34(3):308-311
- CountryChina
- Language:Chinese
-
Abstract:
Axon guidance molecules,slit glycoprotein (Slit) and Roundabout receptors (Robo) were firstly identified in the central neural system of Drosophila melanogaster.The Slit-Robo signal plays a crucial role in axon guidance,inflammation,tumor metastasis and angiogenesis,of which the role of Slit2-Robo pathway in angiogenesis has drawn a greater attention and still remains conflicting.Herein,we provide a review on the role of Slit2-Robo pathway in ocular angiogenesis and vascularization of other organs and systems.We hope this review will be the basis of further study on the mechanism of Slit2-Robo signaling on angiogenesis and provide new target for the therapy on ocular vascular disease
