Texiobactin, a Potent Killer of Antibiotic Resistant Pathogens.
10.4167/jbv.2017.47.2.102
- Author:
Madeeha AROOJ
1
;
Young Sang KOH
Author Information
1. Department of Microbiology and Immunology, School of Medicine and Brain Korea 21 PLUS Program, and Jeju Research Center for Natural Medicine, Jeju National University, Jeju, Korea. yskoh7@jejunu.ac.kr
- Publication Type:Review
- Keywords:
Texiobactin;
Peptidoglycan;
MRSA;
iChip
- MeSH:
Animals;
Anti-Bacterial Agents;
Bacterial Load;
Drug Resistance, Microbial;
Gram-Positive Bacteria;
Methicillin-Resistant Staphylococcus aureus;
Mice;
Peptidoglycan;
Public Health;
Soil;
Streptococcus pneumoniae
- From:Journal of Bacteriology and Virology
2017;47(2):102-104
- CountryRepublic of Korea
- Language:English
-
Abstract:
Antibiotic resistance is a major global concern that primarily affects public health. Texiobactin is a newly discovered antibiotic produces by soil microbes isolated from natural environment. Drug is active against Gram-positive bacteria as it inhibits biosynthesis of peptidoglycan. Infection of methicillin-resistant Staphylococcus aureus (MRSA) and Streptococcus pneumoniae in mice elicits a good response reduce bacterial load. Although extensive efforts have been made to discover new antibiotics but results are still not satisfactory to meet the demands of public health. Recently it has been shown that the discovery of texiobactin by iChip will be a great stone mile to discover more antibiotics.
