The influence of the prognostic nutritional index on postoperative complications and prognosis in patients with resectable non-small cell lung cancer
10.3760/cma.j.issn.1001-4497.2018.10.007
- VernacularTitle:预后营养指数对非小细胞肺癌患者术后并发症和预后的影响
- Author:
Mingran XIE
1
;
Meiqing XU
;
Xiaohui SUN
;
Ran XIONG
;
Jie DENG
;
Hanran WU
;
Shibin XU
Author Information
1. 230001,中国科学技术大学附属第一医院安徽省立医院胸外科
- Keywords:
Carcinoma,non-small-cell lung;
Prognosis;
Prognostic nutritional index
- From:
Chinese Journal of Thoracic and Cardiovascular Surgery
2018;34(10):601-605
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the correlation between the prognostic nutritional index(PNI) and the clinicopathologic features of patients with non-small cell lung cancer(NSCLC),and to compare postoperative complications and survival between patients with High-PNI(H-PNI) and Low-PNI(L-PNI) after operation.Methods This study retrospectively reviewed and analyzed the medical records of 216 patients underwent surgery between July 2010 and December 2011 who were pathologically dignosed with NSCLC.Among these,127 patients with H-PNI,and 89 patients with L-PNI.The clinicopathologic features,median survival time and 5-year survival rates between two groups were analyzed.Results Patients in the L-PNI group had greater pathologic TNM stage,larger tumors,lower Serum albumin levels,and greater percentage of chemotherapy than those in the H-PNI group(P ＜ 0.05).The H-PNI group was associated with significantly fewer postoperative complications than the L-PNI group (P ＜ 0.05).For the patients with H-PNI,the MST was 61.6 months an the 1-,3-,and 5-year OS were 91.3 ％,80.1％,and 74.1％,respectively.For the patients with L-PNI,the MST was 49.9 months and the 1-,3-,and 5-year OS were 82.0％,63.5％,and 53.5％,respectively.There was significant difference in survival between the two groups(P ＜ 0.05).TNM staging and PNI were showed to be independent prognostic factors.Conclusion Different PNI of NSCLC has certain heterogeneity.Patients with H-PNI show better survival and lower postoperative complications rate than those with L-PNI.
