Predictors of survival after treatment of recurrence after esophagectomy
10.3760/cma.j.issn.1001-4497.2018.08.008
- VernacularTitle:食管癌术后单转移灶接受治疗后生存率预测因素
- Author:
Yulong XUAN
1
;
Baojun CHEN
;
Bin CAO
;
Tao WANG
;
Yong ZHOU
;
Minke SHI
Author Information
1. 210008,南京鼓楼医院心胸外科
- Keywords:
Esophagectomy;
Recurrence;
Predictors
- From:
Chinese Journal of Thoracic and Cardiovascular Surgery
2018;34(8):477-480
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the prognostic factors of postoperative single metastasis in patients with esophageal cancer after treatment.Methods The clinical data of patients with single lesion metastasis from 2002 to 2016 were analyzed retrospectively.Demographic and clinicopathologic data were reviewed.Predictors of PRS after definitive therapy for isolated EC recurrence were determined by the multivariable Cox proportional hazards model.Results Of the 1 016 curative esophagectomies,383 patients(37.7%) experienced recurrences(median followup 53 months).114 (11.2%) received definitive treatment of isolated EC recurrence(63 were treated surgically with or without chemotherapy-radiotherapy[CTRT] and 51 received definitive CTRT alone).Median time to recurrence(TTR) was 18 months.The 1-year and 3-year PRSs were 78.9% and 38.6% (median survival 28 months).On multivariable analysis;TTR was the only significant independent predictor for survival after recurrence (HR =0.982,95 % CI:0.95-1.03,P =0.036).No pronounced difference was found in disease-free survival or in PRS between recurrent patients treated with operation with or without CTRT and patients who received definitive CTRT.Conclusion A select subgroup of patients with isolated EC recurrence can be treated with curative intent.TTR was the best predictor for PRS.